News
We send the latest information from SMC Laboratories.
The STAM™ mouse model: a clinically relevant, spontaneous HCC model
We would like to introduce a study published by our client using our STAM™ mouse model (Dow, et al. Proc Natl Acad Sci U S A. 2018). Title: Integrative genomic analysis of mouse and human hepatocellular carcinoma Dow, et al. Proc Natl Acad Sci U S A. 2018 The STAM™ model is…
Hyogo Medical University publishes HBV study featuring our histopathological analysis of hepatic steatosis
SMC is proud to announce that Hyogo Medical University (JPN) has published a study featuring histopathological data evaluated by our scientists here at SMC. Title： Association of PNPLA3 SNP With the Development of HBV-related Hepatocellular Carcinoma (Enomoto H, et al. In Vivo. 2023) The article above looks at the role that Patatin-like phospholipase…
Study published in Cell Metabolism on the efficacy of MGAT2 inhibitor in STAM™
SMC is proud to announce that Bristol-Myers Squibb (NJ) has published the results of their study using our pre-clinical services with the STAM™ model in Cell Metabolism. Title MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity (Cheng et al., Cell Metab 2022)…
Study on the efficacy of dietary supplements in the mdx mouse published in bioRxiv.
SMC is proud to announce that GN Corporation (JPN) has published the results of their study using our pre-clinical services in bioRxiv. Resolution of fibrosis in mdx dystrophic mouse after oral consumption of N-163 strain of Aureobasidium pullulans produced biological response modifier β-glucan (BRMG) (Preethy et al., bioRxiv. 2022) This paper reviews the…
Study on the efficacy of dietary supplements in the STAM™ model published in Cell Death & Disease.
SMC is proud to announce that J2H biotech (KOR) has published the results of their study using our pre-clinical services with STAM™ model in Cell Death & Disease. Title: Inhibition of 11β-hydroxysteroid dehydrogenase 1 relieves fibrosis through depolarizing of hepatic stellate cell in NASH (Lee et al., Cell Death Dis . 2022) This…
Study on the efficacy of dietary supplements in the STAM™ model published in BMJ Open Gastroenterology
SMC is proud to announce that GN Corporation Co. Ltd (JPN) has published the results of their study using our STAM™ model in BMJ Open Gastroenterology. In this study, the authors observed how two β-glucans derived from the AFO-202 and N-163 strains of black yeast, Aureobasidium pullulans, affected the gut microbiota and fecal metabolome…
Drug Efficacy Study in the STAM™ Model Published in Biomedicines.
SMC is proud to announce that MRM Health (BEL) has published the results of their study using our STAM™ model in Biomedicines. ■Title A Nine-Strain Bacterial Consortium Improves Portal Hypertension and Insulin Signaling and Delays NAFLD Progression In Vivo (Pinheiro et al., Biomedicines. 2022) The above study tested the therapeutic effects of a…
SMC client receives award for presentation on study of NASH diagnosis at 40th annual meeting of JSLSM
Today, I would like to share with you some wonderful and exciting news! Recently, a client of ours from the National Defense Medical College, Dr. Yasuhiro Takihata, gave a presentation on NASH diagnostics at the 40th Annual Meeting of the Japanese Society of Laser Medicine (JSLSM) and was awarded the Annual Meeting Award for his…
Drug Efficacy Study in the STAM™ Model Published in Cells
SMC is proud to announce that Cellaïon (BEL) has published the results of their study using our STAM™ model in Cells. ■Title Human Allogeneic Liver-Derived Progenitor Cells Significantly Improve NAFLD Activity Score and Fibrosis in Late-Stage NASH Animal Model ( Najimi et al., Cells. 2022 ) In this study, the authors reported that…
Drug Efficacy Study in the STAM™ Model Published in Gene
SMC is proud to announce that TSUMURA & CO. (JPN) has published the results of their study using our STAM™ model in Gene. ■Title Integrated analysis of effect of daisaikoto, a traditional Japanese medicine, on the metabolome and gut microbiome in a mouse model of nonalcoholic fatty liver disease Ishizawa et al., Gene. 2022…