論文

SMCラボラトリーズは、製薬企業や研究機関のご要望に沿った試験をデザインするコンサルティング型の
CROとして世界的に⾼い評価をいただいています。
特にMASH/NASHの研究分野では、当社独自のSTAM™マウスを用いた薬効評価試験サービスを提供しており、
STAM™マウスを用いた研究成果は雑誌や学会などで多く公表されております。

Publications

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022

No.63

2020

Cell Mol Gastroenterol Hepatol.,

"Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in Liver Tumors in Mice" (Cell Mol Gastroenterol Hepatol. DOI: 10.1016/j.jcmgh.2020.10.010., 2020)
VIEW ARTICLE bug

No.62

2020

Journal of Lipid Research.,

“Insulin resistance dysregulates CYP7B1 leading to oxysterol accumulation: a pathway for NAFL to NASH transition” (J Clin Exp Gastroenterol., DOI: 10.1194/jlr.RA120000924., 2020)
VIEW ARTICLE bug

No.61

2020

Clinical and Experimental Gastroenterology.,

“Changes in Function and Dynamics in Hepatic and Splenic Macrophages in Non-Alcoholic Fatty Liver Disease” (Clin Exp Gastroenterol., DOI: 10.2147/CEG.S248635., 2020)
VIEW ARTICLE bug

No.60

2020

Purinergic Signalling,

“Design and in vivo activity of A3 adenosine receptor agonist prodrugs” (Purinergic Signal., DOI: 10.1007/s11302-020-09715-0., 2020)
VIEW ARTICLE bug

No.59

2020

Cell Reports Medicine,

“Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis” (Cell Rep Med ., DOI: DOI: 10.1016/j.xcrm.2020.100056., 2020)
VIEW ARTICLE bug

No.58

2020

Journal of Biochemical and Molecular Toxicology,

“Omaveloxolone and TX63682 Are Hepatoprotective in the STAM™ Mouse Model of Nonalcoholic Steatohepatitis” (J Biochem Mol Toxicol., DOI: 10.1002/jbt.22526., 2020)
VIEW ARTICLE bug

No.57

2020

Journal of Medicinal Chemistry,

“6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis” (J Med Chem., DOI: 10.1021/acs.jmedchem.0c00542., 2020)
VIEW ARTICLE bug

No.56

2020

Scientific Reports,

“Novel Combinatorial Regimen of Garcinol and Curcuminoids for Non-alcoholic Steatohepatitis (NASH) in Mice” (Sci Rep., DOI: 10.1038/s41598-020-64293-w)
VIEW ARTICLE bug

No.55

2020

Journal of Medicinal Chemistry,

“[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis” (J Med Chem., DOI: 10.1021/acs.jmedchem.9b01440., 2020)
VIEW ARTICLE bug

No.54

2020

Diabetology & Metabolic Syndrome,

“Intracellular toxic advanced glycation end-products (TAGE) in myoblasts may cause sarcopenia: Research article of a non-clinical study” (Diabetol. Metab. Syndr., DOI: 10.21203/rs.2.23269/v1, 2020)
VIEW ARTICLE bug

No.53

2020

European Radiology Experimental,

“Free fatty acid-based low-impedance liver image: a characteristic appearance in nonalcoholic steatohepatitis (NASH)” (Eur Radiol Exp., 4: 3., 2020)
VIEW ARTICLE bug

No.52

2020

Journal of medicinal chemistry,

“Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.” (J Med Chem., DOI: 10.1021/acs.jmedchem.9b01621., 2020)
VIEW ARTICLE bug

No.51

2020

Expert Opinion on Investigational Drugs,

“Pegbelfermin (BMS-986036): an investigational PEGylated fibroblast growth factor 21 analogue for the treatment of nonalcoholic steatohepatitis.” (Expert Opin Investig Drugs. 3:1-9., 2020)
VIEW ARTICLE bug

No.50

2020

JHEP Reports,

“A Blocking Monoclonal Antibody to CCL24 Alleviates Liver Fibrosis and Inflammation in Experimental Models for Liver Damage” (JHEP Reports, 10.1016/j.jhepr.2019.100064, 2020)
VIEW ARTICLE bug