論文

SMCラボラトリーズは、製薬企業や研究機関のご要望に沿った試験をデザインするコンサルティング型の
CROとして世界的に⾼い評価をいただいています。
特にMASH/NASHの研究分野では、当社独自のSTAM™マウスを用いた薬効評価試験サービスを提供しており、
STAM™マウスを用いた研究成果は雑誌や学会などで多く公表されております。

Publications

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022

No.30

2017

The FASEB Journal,

“Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma“ (FASEB J, DOI:10.1096/fj.201700866R, 2017)
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No.29

2017

Oncotarget,

“MicroRNA deregulation in nonalcoholic steatohepatitisassociated liver carcinogenesis” (Oncotarget, 8:88517-88528, 2017)
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No.28

2017

Oncotarget,

“Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet” (Oncotarget, 8:39978-39993, 2017)
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No.27

2017

Physiological Research,

“Pathophysiological analysis of the progression of hepatic lesions in STAM™ mice.” (Physiological Research, 66:791-799, 2017)
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No.26

2017

Molecular Cancer Research,

“Inhibition of the cell death pathway in non-alcoholic steatohepatitis (NASH)-related hepatocarcinogenesis is associated with histone H4 lysine 16 deacetylation” (Molecular Cancer Research, DOI:10.1158/1541-7786.MCR-17-0109, 2017)
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No.25

2017

Magnetic Resonance Imaging,

“The natural history of streptozotocin-stimulated non-alcoholic steatohepatitis mice followed by Gd-EOB-DTPA-enhanced MRI: Comparison with simple steatosis mice.” (Magn Reson Imaging, 38:123-128, 2017)
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No.24

2017

Journal of Pharmacology and Experimental Therapeutics,

“Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis” (J Pharmacol Exp Ther, 360:1-13, 2017)
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