論文

SMCラボラトリーズは、製薬企業や研究機関のご要望に沿った試験をデザインするコンサルティング型の
CROとして世界的に⾼い評価をいただいています。
特にMASH/NASHの研究分野では、当社独自のSTAM™マウスを用いた薬効評価試験サービスを提供しており、
STAM™マウスを用いた研究成果は雑誌や学会などで多く公表されております。

Publications

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022

No.37

2018

NPJ Precision Oncology,

"Transcriptomic analysis of hepatocellular carcinoma reveals molecular features of disease progression and tumor immune biology" (NPJ Precis Oncol., DOI: 10.1038/s41698-018-0068-8, 2018)
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No.36

2018

Cellular and Molecular Gastroenterology and Hepatology,

"Dipeptidyl Peptidase 4 inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice" (CMGH, DOI: 10.1016/j.jcmgh.2018.08.008, 2018)
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No.35

2018

Glycoconjugate Journal,

“Identification of unique glycoisoforms of vitamin D-binding protein and haptoglobin as biomarker candidates in hepatocarcinogenesis of STAM™ mice” (Glycoconj J., Oct;35(5):467-476, 2018)
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No.34

2018

Proc Natl Acad Sci U S A,

“Integrative genomic analysis of mouse and human hepatocellular carcinoma” (Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.1811029115, 2018)
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No.33

2018

Liver Cancer,

“Effects of a DPP4 Inhibitor on Progression of NASH-related HCC and the p62/ Keap1/Nrf2-Pentose Phosphate Pathway in a Mouse Model” (Liver Cancer, DOI: 10.1159/000491763, 2018)
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No.32

2018

PLoS One,

“Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH” (PLoS One, 13(5): e0194568 , 2018)
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No.31

2018

World Journal of Gastroenterology,

“Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma” (World J Gastroenterol, 24(18):1989-1994, 2018) 
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