Our Focus on Immuno-Oncology

In the field of immuno-oncology, the STAM™ mouse is the most pathologically suitable model for developing new therapeutic drugs for liver cancer.

The utilization of STAM™ mouse enables non-clinical research for the development of liver cancer therapeutics targeting immune cells, tumor microenvironment, and genetic mutations.

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NEWS RELEASE

A New Phase in MASH Therapeutics: Resmetirom (THR-β Agonist) and Semaglutide (GLP-1 Receptor Agonist)

In 2024, the U.S. FDA approved Resmetirom (a THR-β agonist) as the first therapeutic agent for MASH. In August…

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EVENT

SMC Laboratories to Participate in BIO-Europe 2025 (Austria) Online

SMC Laboratories will be participating digitally in BIO-Europe 2025, one of the largest bio-health conventions…

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Stem Cell Res Ther.

MicroRNA-4516 in extracellular vesicles-derived mesenchymal stem cells suppressed integrin αV-mediated lung fibrosis ( doi: 10.1186/s13287-025-04559-0.)

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CDAHFD Model

The CDAHFD model is a widely used and well-characterized model for the evaluation of pharmacological efficacy of new treatments against liver inflammation, liver fibrosis and fatty liver diseases such as MASLD (formerly: NAFLD).

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SMC Laboratories is a global non-clinical CRO supporting drug development in the preclinical phase. We provide consultation and conduct pharmacology studies for novel therapeutics across Inflammation, Fibrosis, Oncology, and Immunology. Our proprietary STAM™ Mouse enables evaluation in MASH, Liver Fibrosis, and HCC, while our portfolio also includes widely used models such as the Bleomycin-induced IPF model, the UUO model for Chronic Kidney Disease (CKD), and the DSS model for Inflammatory Bowel Disease (IBD).

SERVICE

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CDAHFD Model

mouseNAFLD

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APAP-induced acute liver failure model

ALFmouse

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STAM™ Model | MASH & Fibrosis & HCC

MASH/NASH-HCCmouse

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Bleomycin-induced pulmonary fibrosis model

IPFmouserat

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Porcine Pancreatic Elastase (PPE) model

COPDmouse

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New stage

We can introduce disease mice models related to inflammation, fibrosis, metabolic disorder, cancer, and cancer immunity, including the STAM™ mouse, the world's first MASH model mouse developed in our company.

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New stage

SMC Laboratories,Inc.

COMPANY

At SMC Laboratories, we support drug research with our cutting-edge non-clinical pharmacology studies to quickly deliver therapeutic drugs to patients suffering from diseases that cannot be treated with existing drugs.

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PUBLICATION

At SMC Laboratories, we support drug research with our cutting-edge non-clinical pharmacology studies to quickly deliver therapeutic drugs to patients suffering from diseases that cannot be treated with existing drugs.

NEWS

2025.11.03

Made-to-Order Service Example: Optimization of an ANIT-Induced Chronic Cholestasis Model for Drug Efficacy Evaluation

SMC Laboratories’ Made-to-Order (MTO) service is designed to meet research needs that are difficult to reprodu…

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2025.10.28

PRODUCTS AND SERVICE

Made-to-Order Service Example: Development of a Polycystic Kidney Disease Model Using DBA/2FG-pcy Mice

The DBA/2FG-pcy mouse is an autosomal recessive model of polycystic kidney disease that spontaneously develops…

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2025.10.27

EVENT

SMC Laboratories to Participate in BIO-Europe 2025 (Austria) Online

SMC Laboratories will be participating digitally in BIO-Europe 2025, one of the largest bio-health conventions…

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2025.10.21

PRODUCTS AND SERVICE

Made to Order Case Study: Establishment of Cecal Cannulation Dosing in a Colitis Model

SMC Laboratories’ MTO (Made to Order) service is designed to address research needs that cannot be met by exis…

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2025.10.14

PRODUCTS AND SERVICE

Made to Order Case Example: Establishment of a Unilateral Ureteral Obstruction (UUO) Model in Guinea Pigs

SMC Laboratories’ MTO (Made to Order) service is designed to address evaluation needs that cannot be met with …

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2025.10.03

Poster Presentation at APASL STC 2025 Tokyo

We are pleased to announce that we presented a poster at APASL STC 2025 Tokyo, under Poster ID PF1-5 10244. Ti…

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