News
We send the latest information from SMC Laboratories.
Case study: Study published in Biomolecules on the effects of MSC-sEV in skin fibrosis of BLM-SSc model.
We introduce a case study of drug efficacy evaluation of Mesenchymal stem/stromal cell-derived small extracellular vesicles (MSC-sEVs) using our Systemic sclerosis (SSc) model, BLM-SSc model. Title: An Assessment of Administration Route on MSC-sEV Therapeutic Efficacy ( Zhang B et al., Biomolecules. 2024 ) Article Link ► [DOI: 10.3390/biom14060622] In this study, we administered intraperitoneally, subcutaneously,…
Announcement of webinar: THRβ agonist and preclinical pharmacology study using by STAM™ mice
Today, we are excited to invite you to join our webinar that will be taking place on June 20 from 9:30 AM (JST). In this webinar, we will introduce the THRβ agonist and preclinical pharmacology study. It has been several months since Resmetirom was approved by the FDA as the first MASH treatment. We will…
Why is Chronic Kidney Disease so hard to research?
Between 9 – 12% of the worlds population suffers from Chronic Kidney Disease (CKD), but with no cure, how can we develop more effective therapies for this underserved population? –What is chronic kidney disease? CKD is a persistent loss of kidney function and structural abnormalities that are assessed using markers of kidney damage and histological…
What is proteinuria’s role in evaluating the progression of CKD?
When discussing our mouse models for chronic kidney disease (CKD), we are often asked about proteinuria as a urinary marker of kidney damage. As an important marker used in clinical trials, it's also an important endpoint to look at in non-clinical research as well. Proteinuria data in the Adriamycin model The graph above shows…
What is the relationship between NASH and Liver Cancer?
You may know that liver cancer is one of the most prevalent cancers, but do you know about its relationship with nonalcoholic steatohepatitis (NASH), which is rapidly increasing as a liver disease? The existence of NAFLD-related HCC, which we at SMC Laboratories, Inc. have been focusing on for more than 10 years, is now being…
Long-COVID, COVID-19 variants, and the emergence of pulmonary fibrosis in recovered COVID-19 patients
COVID-19 is a virus belonging to the beta-coronavirus class, similar to the virus that causes severe acute respiratory syndrome (SARS). It has been reported that fibrosis could begin to be observed several weeks after infection during the SARS epidemic. In subsequent follow-up studies, more than 20% of SARS survivors at one year later had pulmonary…
The virtual 81st Scientific Sessions of the American Diabetes Association® and updated information on our original NASH-HCC model (STAM™)
We recently made a presentation on our STAM™ mouse at the 81st Annual Meeting of the American Diabetes Association (June 25 to 29, 2021). The abstract of the presentation has been published in Diabetes. 209-LB: RNA-Seq Analysis of Liver from Diabetic and NASH Model Mouse Treated with Streptozotocin, High-Fat Diet | Diabetes (diabetesjournals.org)