News
We send the latest information from SMC Laboratories.
Introduction of [Pathway MAP of MASH compounds] to accelerate your research
When conducting non-clinical research, it is important to choose an appropriate mouse model that reproduces human pathology and also allows your compound to be evaluated. In this post you will find the appropriate model mouse for your compound and the results. As a pioneer in the field of MASH/NASH, we have conducted more…
Preclinical COPD study with positive controls, Roflumilast
Today, we share an update regarding new preclinical service. It is now possible to use a positive control (Roflumilast) in a drug efficacy evaluation study using PPE-induced COPD model. The drug used as a positive control is roflumilast, a PDE-4 inhibitor. Mean linear intercept by histological analysis of the lungs, the primary endpoint…
Introduction of Chronic Kidney Disease Mice Models
I am writing you today to share some information on our chronic kidney disease (CKD) models. CKD is a condition that is characterized by abnormalities in the structure or function of the kidneys. It is a global public health problem and causes a rising incidence and prevalence of kidney failure with poor outcomes. However,…
MOA demonstration #1 【microbiota】| MASH treatment and fibrosis prevention study targeting gut microbiota in STAM mice
Today, we would like to introduce a demonstration example of a drug efficacy evaluation test of a bacterial consortium consisting of nine types of intestinal resident bacteria using STAMTM mouse (hereinafter “STAM mouse”), which was published in May 2022 in the journal Biomedicines by a research team from Belgium’s MRM Health. I would like to…
Introduction of bleomycin-induced SSc-ILD model
Today, we would like to introduce a more clinically correlative model in which skin and lung fibrosis develop simultaneously. Systemic scleroderma is a progressive, rare disease that causes fibrosis not only in the skin but also in tissues throughout the body, including the heart, lungs and kidneys. Pulmonary disease is a complication that has…
STAM™ mice study: demonstration of MSCs-based cell therapy study for the NASH treatment
We introduce an example of a drug evaluation study on the efficacy of cell therapy in the treatment of NASH using our STAM™ mice, model of non-alcoholic steatohepatitis (NASH). Title: Human Allogeneic Liver-Derived Progenitor Cells Significantly Improve NAFLD Activity Score and Fibrosis in Late-Stage NASH Animal Model ( Najimi et al., Cells. 2022 ) Article…
Acute Liver Failure Mouse Model Lineup
Acute liver failure (ALF) carries a high mortality of approximately 40%, which is caused by virus infections (hepatitis A, B and E), drug-induced liver injury (acetaminophen/paracetamol) or autoimmune hepatitis. ALF exhibits symptoms of severe injury such as destruction of hepatocytes or decrease in liver function due to massive necrosis and inflammation. We have lineup…
New Service: In Vitro Assay for Fibrosis Evaluation
We are delighted to announce the launch of our new in vitro assay service for fibrosis evaluation. By launching this service, we now offer a cost-effective and efficient way to conduct preliminary studies and screen compounds for potential fibrotic effects, saving valuable time and resources in your drug development journey. This not only speeds…
Introducing our new pulmonary fibrosis model: Silica-induced pulmonary fibrosis model
Today, we are pleased to announce that we have expanded our preclinical model lineup by including the “Silica-induced pulmonary fibrosis model”. Pulmonary fibrosis in silica models occurs early and is maintained long term. Hence, this model is one of the most beneficial model mice for therapeutic study for pulmonary fibrosis. In general, human pulmonary…
Introduction of Inflammatory Bowel Disease mouse model
Today, we give you a brief introduction to the dextran sulfate sodium (DSS) -induced colitis model, which is a clinically representative mouse model that can be used to conduct drug efficacy studies targeting Inflammatory Bowel Disease. This model is widely used to elucidate the mechanism of IBD pathogenesis and evaluate drug candidates because of…