| A must for IPF researchers! | Suggestions for the best disease model for your research

If you are considering a drug efficacy study using a mouse model of lung fibrosis, you should use a model that best suits your purpose, rather than a generic study design for that model. The bleomycin-induced lung fibrosis model is widely used for drug efficacy studies, and the general study design for it is publicly available.

Due to the abundance of established data on previous common study design-based trials, it is likely that said study designs will be used for most future trials. However, this is not always the most effective way to evaluate your compounds; instead, it is best to use study designs that can effectively reproduce the pathology that matches your compound’s indications.

In many cases, contractors are not well-versed in what their clients want in terms of research, and therefore cannot effectively perform studies. They also may have little experience in the studies of choice, thus ensuring they are able to propose adequate study designs.

As a [consulting CRO specializing in non-clinical research], we have conducted more than 150 drug efficacy evaluation studies using IPF model mice and have evaluated many IPF therapeutic candidates. Based on our extensive experience, we can offer you a drug evaluation study design that is appropriate for you.

The image below shows an example study design for the general bleomycin model and an example long-term dosing study design for researchers who are considering cell therapy or other treatments.



The above study designs include general analysis items, some of which we share below. Below is the data on lung fibrosis, which is most likely of great interest to you.



As you can see from the information above, lung fibrosis occurs over a long period of time and can be analyzed at any point in time.

Are you interested in other data included in the analysis?
Detailed results can be found here.

To reiterate, if you are considering a study to assess drug efficacy in a mouse model of lung fibrosis, you should use a study design that is optimal for your purpose. Study designs that provide suitable pathologies for the evaluation of your compound will provide optimal results.

Having conducted more than 150 drug evaluation studies in IPF mouse models, we are confident that we can provide you with the best services to suit your needs.