Study published in Int. J. Mol. Sci. on the efficacy of Mesenchymal stromal cell/stem cell small extracellular vesicles (MSC-sEV) in STAM™

SMC is proud to announce that Agency for Science, Technology and Research (A*STAR) (SGP) has published the results of their study using our pre-clinical services with the STAM™ model in Int. J. Mol. Sci.



MSC−sEV Treatment Polarizes Pro−Fibrotic M2 Macrophages without Exacerbating Liver Fibrosis in NASH

(Zhang et al., Int J Mol Sci., 2023)


In this study, the efficacy of mesenchymal stromal cell/stem cell small extracellular vesicles (MSC-sEV) in the treatment of NASH is being evaluated.

Authors show that compared to STAM™ mice in the vehicle-treated group, NASH-phase STAM™ mice treated with MSC-sEV had significantly lower NAFLD activity score (the main clinical endpoint for evaluating fatty liver) and fibrosis area in the liver. These Results suggest that MSC-sEV may be useful in the treatment of NASH.


The STAM™ mouse is the world's first pathological mouse model to show the progression of NASH to liver cancer, and was developed here at SMC Laboratories. This model shows a similar pathology to human NASH (steatosis → NASH → liver fibrosis → HCC). Therefore, the STAM™ model has been used in many efficacy studies, as well as in basic research.


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