Made-to-Order Service Example: Optimization of an ANIT-Induced Chronic Cholestasis Model for Drug Efficacy Evaluation
SMC Laboratories’ Made-to-Order (MTO) service is designed to meet research needs that are difficult to reproduce with existing models by custom-designing and building optimal models or administration routes from scratch based on client requirements.
In this case, we optimized an ANIT (α-naphthyl isothiocyanate)-induced cholestatic liver injury model to evaluate the efficacy of a client’s compound targeting cholestatic liver disease.
Study Overview
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Designed ANIT dosing regimen, frequency, and observation period to reproduce chronic cholestasis
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Conducted biochemical analyses (ALT, ALP, T-Bil) and histological evaluation (Sirius Red staining)
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After confirming model stability and reproducibility, evaluated the compound’s anti-cholestatic and anti-fibrotic effects
Results
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Successfully established a chronic cholestasis disease model
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Achieved a reproducible model with clear biomarker changes suitable for detecting pharmacological effects
At SMC Laboratories, we provide flexible model design and reliable data acquisition tailored to disease mechanisms and drug actions, offering strong support for preclinical research and development.
If you ever feel that “existing models are not enough,” please contact us to explore our MTO service.