Made-to-Order Service Example: Development of a Polycystic Kidney Disease Model Using DBA/2FG-pcy Mice
The DBA/2FG-pcy mouse is an autosomal recessive model of polycystic kidney disease that spontaneously develops renal cysts due to a mutation in the NPHP3 gene.
Using this model, Tolvaptan was set as a positive control, and a histopathological evaluation system was established based on hematoxylin and eosin (HE) staining to quantify cystic lesions.
Through this Made-to-Order project, we successfully developed a study platform enabling the evaluation of therapeutic effects on renal cyst formation.
This customized model can be applied flexibly to nonclinical efficacy studies in the kidney disease field, supporting the early stages of drug discovery and development.