Made to Order Case Example: Establishment of a Unilateral Ureteral Obstruction (UUO) Model in Guinea Pigs
SMC Laboratories’ MTO (Made to Order) service is designed to address evaluation needs that cannot be met with existing disease models. We design and build new models tailored to the client’s research objectives, optimizing species, disease, and evaluation systems, and supporting the entire process from model establishment to main study execution.
A unilateral ureteral obstruction (UUO) model in guinea pigs was designed and established from scratch. This approach was taken to build an appropriate pharmacological evaluation system for compounds that are difficult to evaluate in mice or rats.
【Study Outline】
・Optimized surgical technique and postoperative care protocol specific to the species
・Established reproducible disease pathology and quantitative fibrosis assessment using Sirius Red and PAS staining
・Defined model success criteria and transitioned to the main study in a short period
【Outcome】
・Successfully established a novel UUO model in guinea pigs
・Developed a study system enabling quantitative fibrosis evaluation and applied it to the main study
・Provided a solution in a specialized model area where conventional CROs have limited capability
Through initiatives like this, SMC Laboratories provides flexible model design and reliable data acquisition to strongly support drug discovery research. Please feel free to contact us to discuss your study design and evaluation needs.