Introducing our new model: DDC-induced liver injury model

We introduce the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced liver injury model*, a well-known model of cholestatic liver disease and a new model we have started offering our services as.


Using the DDC-induced liver injury model, cholangitis and liver fibrosis can be assessed as follows.



 As well as the DDC-induced liver injury model described above, we have also Concanavalin A and D-gal/LPS-induced acute hepatitis models, and NASH mouse models of the liver disease model mouse.

For more information on our mouse model, please click here.



Features of the DDC model mouse

Clerosing cholangitis and cholangiohepatic fibrosis following protoporphyrin accumulation in the bile ducts

High survival rates and reproducibility compared to the surgical BDL model

Reproducing the main histopathological features of human biliary stasis disease