Clear Negative Correlation Between FVC and Ashcroft Score in Bleomycin-Induced Lung Fibrosis Model
In preclinical drug development for fibrotic lung diseases, the ability to quantitatively and reproducibly assess disease severity is essential.
At SMC Laboratories, we evaluated the relationship between lung function and histopathological fibrosis in the bleomycin-induced lung fibrosis mouse model. Specifically, we analyzed the correlation between forced vital capacity (FVC) and the Ashcroft histological fibrosis score.
Our findings revealed a strong negative correlation (r = 0.7743) between FVC and the Ashcroft score (see figure below).
This indicates that as fibrosis progresses, lung compliance decreases, resulting in reduced FVC — a hallmark of pulmonary function impairment.
This data supports the model’s utility in preclinical efficacy studies by allowing dual evaluation from both functional and pathological perspectives.