News
We send the latest information from SMC Laboratories.
A study using liver samples from the STAM™ model published in PLOS ONE.
SMC is proud to announce that Institut de Recherches Servier (FRA) has published the results of their study using our STAM™ model liver samples in PLOS ONE. Title ”Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression“ In this paper, the authors compared the extent to which C-Proteinase…
SMC announces Presentation of New Data at the International Congress of Endocrinology 2022 (ICE2022).
Today, we are pleased to announce the acceptance of our abstract on our NASH-hepatocellular carcinoma (HCC) model at the International Congress of Endocrinology 2022 (ICE2022) 【Online】, which is to be held on August 25th and 28th. Our presentation will be entitled “RNA-seq Analysis of Liver from NASH-HCC Model Mouse Treated with Streptozotocin-High Fat Diet”. …
Drug Efficacy Study in the STAM™ Model Published in Translational Oncology
SMC is proud to announce that Kurume University (JPN) has published the results of their study using our STAM™ model in Translational Oncology. Title “Efficacy and tolerability of Sorafenib plus metronomic chemotherapy S-1 for advanced hepatocellular carcinoma in preclinical and clinical assessments“ In this study, the authors evaluated the anti-tumor effect of combining sorafenib…
GN Corporation publication in Journal of Clinical and Experimental Hepatology
SMC announces that GN Corporation Clinical and Experimental Hepatology (Japan) has published the results of a study using STAM™ mouse model in Clinical and Experimental Hepatology. Title: “Hepatoprotective effects of Aureobasidium pullulans derived b1,3-1,6 glucans in a murine model of non-alcoholic steatohepatitis” For detailed information, see the below URL. Hepatoprotective effects of Aureobasidium…
Esperion Therapeutics's publication in Cell Metabolism
SMC announces that Esperion Therapeutics (MI, USA) has published the results of a study using STAM™ mouse model in Cell Metabolism. Title: “Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia” For detailed information, see the below URL. Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia – PubMed (nih.gov)
Drug efficacy studies in NASH mouse model
We would like to introduce a study published by our client using our proprietary non-alcoholic steatohepatitis (NASH) model called STAM™ (Ikewaki et al., bioRxiv, 2021). In this study, the authors evaluated how the single or combined consumption of two β-glucans derived from the AFO-202 and N-163 strains of black yeast, Aureobasidium pullulans, affected the…
Drug efficacy study in NASH mouse model
We would like to introduce a paper published by our client using our non-alcoholic steatohepatitis (NASH) model. (Murakami et al., Cells., 2022). In this paper, the authors evaluated the effect of pemafibrate, a selective PPARα modulator, and tofogliflozin, an inhibitor of Na+/glucose-conjugated transport carrier 2, alone and in combination on the progression of NASH…
Published papers with IPF model
We would like to share with you some examples of studies that our clients have often asked us about using the IPF model. CohBar, Inc. (NASDAQ: CWBR), a clinical-stage biotechnology company developing mitochondria-based therapeutics also announced interesting data with our IPF model at the American Thoracic Society’s Virtual 2020 Conference. The ePoster presents…
National Defense Medical College's publication in Surgery Open Science
SMC announces that National Defense Medical College (Japan) has published the results of a study using STAM™ mouse model in Surery Open Science. Title: “In vivo diffuse reflectance spectroscopic analysis of fatty liver with inflammation in mice” In this paper, they report the usefulness of diffuse reflectance spectroscopy, which does not require tissue collection,…
Our clients’ presentations at DDW 2021
Our clients presented data on treatment of NASH using STAMTM model at the DDW2021 (May 21-23). For detailed information, see the below URL. https://ddw.org/attendee-planning/online-planner/ Poster #Sa373 BOFUTSUSHOSAN, A TRADITIONAL JAPANESE MEDICINE, MAINTAINS THE GUT MICROBIOME AND AMELIORATES PROGRESSION OF LIVER DISORDER IN DIABETES INDUCED NASH MODEL MICE Institution: Hokkaido University (Japan)