SMC MODELS
D-gal/LPS-induced acute liver failure model
The D-gal/LPS-induced acute liver failure model
The D-gal/LPS-induced acute liver failure model is made by combination of D-galactosamine and lipopolysaccharide to induce acute liver injury with a rapid and efficient disease onset. The combination of D-gal/LPS induces robust liver inflammation and apoptosis via immune response.
A single shot of D-gal/LPS is administered intraperitoneally to 6-weeks old, male C57BL/6J mice which then develop severe and acute liver injury in just 6h. This model is particularly useful for the pharmaceutical drug evaluation of drug candidates against viral- or drug-induced hepatitis and acute liver failure.
Comparison of different acute liver failure (ALF) models
For a more in-depth information on each model feel free to check out our other ALF models:
CCl4 Acute Liver Failure Model
Concanavalin A Acute Liver Failure Model
APAP Acute Liver Failure Model
Analysis items and key endpoints
Histopathological analysis
HE Staining for evaluation of necrosis / inflammation
Immunohistochemistry
For different molecular markers
Biochemistry analysis
ALT
AST etc.
Gene expression analysis
TNF-α
IL-6 etc.
Cytokine analysis
TNF-α
IL-6 etc.
Contact us
If you would like to discuss which of the available acute liver failure models fits best to your drug development approach, please feel free to reach out to us using the contact button below. We are looking forward to your inquiry!