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You can view the research column published every month by SMC Laboratories.
2025.01.29
Pre-clinical studies for Cholestatic Liver Diseases: Bile Duct Ligation model
We would like to share with you about our Bile duct ligation (BDL) model, known as a disease model mice for cholestatic liver disease. This model reproduces the pathological features of cholestatic liver disease, which leads to acute liver injury followed by liver inflammation and severe fibrosis. It is a useful model for…
2025.01.29
Positive control for CCl4 mouse model
We would like to introduce our carbon tetrachloride (CCl4)-induced liver fibrosis model, which is a widely used and reliable animal model of cirrhosis. The CCl4-induced liver fibrosis model is a model that forms bridging fibrosis around the portal vein region. While our STAM™ model develops mild liver fibrosis, the CCl4 model develops severe cirrhosis-like…
2025.01.29
Proteinuria in the Adriamycin model
When discussing our mouse models of chronic kidney disease (CKD), we are often asked about proteinuria as a urinary marker of kidney damage. As an important marker used in clinical trials, it’s also an important endpoint to look at in non-clinical research. Proteinuria data in the Adriamycin model Above is the time-course data of…
2025.01.29
Drug efficacy evaluation study for fibrotic diseases involving multiple organs
We want to introduce a paper by Insilico Medicine, a company that focuses on fibrosis to develop drugs, and after conducting pre-clinical studies in mice at our company, submitted the results of their research to Nature Biotechnology. Ren et al., Nat Biotechnol., 2024 This article identifies TRAF2- and NCK-interacting kinase (TNIK) as an anti-fibrotic…
2025.01.29
Introduction of the paper using our UUO model
Today, we would like to introduce a paper published by our client using our Chronic Kidney Disease model. In this paper, the authors reported an improved pathology, and analyzed the mechanism of the UUO-induced kidney fibrosis model by histological and gene expression analysis after the administration of their compounds. About the UUO model…
2025.01.29
Positive control for UUO kidney fibrosis
We would like to introduce about a newly established positive control – an ALK5 inhibitor – for our UUO-induced renal fibrosis model. This ALK5 inhibitor has an inhibitory effect on the TGF-beta/ALK5 signaling pathway, which plays a central role in renal fibrosis. Below is the result of fibrosis analysis from an ALK5 inhibitor study in…
2025.01.29
Adenine-induced nephropathy model
We would like to introduce our Adenine-induced nephropathy mouse model, a chronic kidney disease (CKD) model. Chronic kidney disease (CKD) is a progressive loss in kidney function. Kidney function is measured by Glomerular Filtration Rate (GFR), and blood biomarker (Serum creatinine and BUN). Due to the continuous decline in kidney function, the condition of…
2025.01.29
Biomarker for kidney damage in Adriamycin model
We would like to introduce a non-invasive biomarkers for kidney disease models. Urine NGAL levels in ADR model at Day28 Generally, eGFR is calculated using creatinine and is used to diagnose chronic kidney disease (CKD). However, when the effect on the kidney is weak, issues such as slow or no change are…
2025.01.29
Adriamycin-induced nephropathy model
We would like to introduce a chronic kidney disease (CKD) and our Adriamycin-induced nephropathy (ADR) mouse model. Chronic kidney disease (CKD) is a progressive loss in kidney function. 1 in 10 people have some degree of kidney disease and every year millions die prematurely of complications related to CKD. About 1% of CKD patients…
2025.01.28
Supporting non-clinical immunotherapy drug development for HCC; new utilization of STAM HCC model
We would like to introduce the features of the STAMTM-HCC/IO+ model as a liver cancer model. For your reference, we hope you will also visit our special website at the URL below. https://www.smccro-lab.com/Immuno-oncology/en/ Liver cancer, primarily HCC, is the fourth most common cancer in the world (Huang DQ et al, Nature Reviews Gastroenterology &…
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