SMC is proud to announce that GN Corporation (JPN) has published the results of their study using our pre-clinical services in bioRxiv.

 

Resolution of fibrosis in mdx dystrophic mouse after oral consumption of N-163 strain of Aureobasidium pullulans produced biological response modifier β-glucan (BRMG)

(Preethy et al., bioRxiv. 2022)

 

This paper reviews the results of a drug efficacy study that was conducted here at SMC Laboratories using the mdx mice.

The mdx Mice is a widely used pathological model which has a similar pathogenesis to Duchenne muscular dystrophy in humans.

 

In this paper, mdx mice were treated with a β-glucan derived from the N-163 strain of Aureobasidium pullulans. At the end of the study it was found that the yeast-derived β-glucan was successful in preventing muscle inflammation and fibrosis.

This was evaluated via the inflammation score, which is calculated by looking at the level of inflammatory cell infiltration and fibrosis in Masson’s Trichome stained muscle sections. In this study, the inflammation score of the β-glucan-treated mice was lower compared to the normal group.

These results suggest that β-glucans can be used as an adjuvant to slow the progress of Duchenne muscular dystrophy.

►For more information on this paper, click here.

 

The test compound used in this paper has previously been shown to have anti-inflammatory and anti-fibrotic effects in other models as well, including our NASH model (STAM™).

 

Here at SMC, we offer a robust set of disease models and can work with many different modalities. We also have a lot of experience conducting repeat studies for our clients so that they can discover the necessary dosage, administration route, and treatment period for their compound.

 

The mdx mice that was used in this paper was a model that we had no experience with prior to this study. However, we were able to work with GN Corporation to successfully establish and modify the model.

So if you are looking to use a model that we do not currently have on our lineup, or would like to modify one of our existing models to fit the needs of your study, then please do not hesitate to let us know. We would love the opportunity to help you create a study plan that is perfect for your project.